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Article

Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia.

Nature communications - 10 Jan 2022

Andreu-Bernabeu Álvaro, Díaz-Caneja Covadonga M, Costas Javier, De Hoyos Lucía, Stella Carol, Gurriarán Xaquín, Alloza Clara, Fañanás Lourdes, Bobes Julio, González-Pinto Ana, Crespo-Facorro Benedicto, Martorell Lourdes, Vilella Elisabet, Muntané Gerard, Nacher Juan, Molto María Dolores, Aguilar Eduardo Jesús, Parellada Mara, Arango Celso, González-Peñas Javier

Abstract excerpt

Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control sample (N = 3,488). We then subset schizophrenia predisposing variation based on its effect on LNL-ISO. We find that genetic variation with concordant effects in both phenotypes shows significant...

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Identifiers

PMID: 35013163
DOI: 10.1038/s41467-021-27598-6
PMCID: PMC8748758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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