Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shared Genetic Determinants of Schizophrenia and Autism Spectrum Disorder Implicate Opposite Risk Patterns: A Genome-Wide Analysis of Common Variants.

Schizophrenia bulletin - 8 Nov 2024

Chen Yu, Li Wenqiang, Lv Luxian, Yue Weihua

Abstract excerpt

BACKGROUND AND HYPOTHESIS: The synaptic pruning hypothesis posits that schizophrenia (SCZ) and autism spectrum disorder (ASD) may represent opposite ends of neurodevelopmental disorders: individuals with ASD exhibit an overabundance of synapses and connections while SCZ was characterized by excessive pruning of synapses and a reduction. Given the strong genetic predisposition of both disorders, we propose a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autism Spectrum Disorder
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 38616054
DOI: 10.1093/schbul/sbae044
PMCID: PMC11548934

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shared Genetic Determinants of Schizophrenia and Autism Spectrum Disorder Implicate Opposite Risk Patterns: A Genome-Wide Analysis of Common Variants.PMID 38616054Read ↗

Synaptic and Gene Regulatory Mechanisms in Schizophrenia, Autism, and 22q11.2 CNV Mediated Risk for Neuropsychiatric DisordersSemantic proximity Read ↗

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders.Semantic proximity Read ↗

Joint analysis of de novo mutations from autism spectrum disorder, schizophrenia, congenital heart disease, and other developmental disorders improves detection power and implicates shared molecular pathways and CNS processes.Semantic proximity Read ↗

Uncovering convergence and divergence between autism and schizophrenia using genomic tools and patients' neurons.Semantic proximity Read ↗

Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders.Semantic proximity Read ↗

Genetics implicate common mechanisms in autism and schizophrenia: synaptic activity and immunity.Semantic proximity Read ↗

Uncovering convergence and divergence between autism and schizophrenia using genomic tools and patients’ neuronsSemantic proximity Read ↗

Uncovering convergence and divergence between autism and schizophrenia using genomic tools and patients’ neuronsSemantic proximity Read ↗

Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.Semantic proximity Read ↗

Rare schizophrenia risk variants are enriched in genes shared with neurodevelopmental disordersSemantic proximity Read ↗

Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity.Semantic proximity Read ↗

Polygenic Dissection of Synaptic Pruning and Glutamatergic Signaling: Contrasting Mechanisms in ASD and ADHDSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.