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Article

Discordant associations of educational attainment with ASD and ADHD implicate a polygenic form of pleiotropy.

Nature communications - 11 Nov 2021

Verhoef Ellen, Grove Jakob, Shapland Chin Yang, Demontis Ditte, Burgess Stephen, Rai Dheeraj, Børglum Anders D, St Pourcain Beate

Abstract excerpt

Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are complex co-occurring neurodevelopmental conditions. Their genetic architectures reveal striking similarities but also differences, including strong, discordant polygenic associations with educational attainment (EA). To study genetic mechanisms that present as ASD-related positive and ADHD-related negative genetic correlations...

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Share to Attention Deficit Disorder with Hyperactivity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 34764245
DOI: 10.1038/s41467-021-26755-1
PMCID: PMC8586371

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