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Article

Small cell transformation of non-small cell lung cancer under immunotherapy: Case series and literature review.

Thoracic cancer - 1 Nov 2021

Imakita Takuma, Fujita Kohei, Kanai Osamu, Okamura Misato, Hashimoto Masayuki, Nakatani Koichi, Sawai Satoru, Mio Tadashi

Abstract excerpt

In advanced lung cancer treatment, immunotherapy provides durable responses in some patients. However, other patients experience progressive disease and the resistance mechanisms to immunotherapy have yet been fully elucidated. Small cell transformation of non-small cell lung cancer (NSCLC) is commonly recognized as one of the resistance mechanisms to epidermal growth factor receptor (EGFR)-tyrosine kinase...

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Identifiers

PMID: 34622569
DOI: 10.1111/1759-7714.14180
PMCID: PMC8590890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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