Neurodevelopmental effects of genetic frontotemporal dementia mutations revealed by total intracranial volume differences.

doi:10.1177/13872877251393414

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Article

Neurodevelopmental effects of genetic frontotemporal dementia mutations revealed by total intracranial volume differences.

Journal of Alzheimer's disease : JAD - 1 Jan 2026

So Isis, Bouzigues Arabella, Russell Lucy L, Foster Phoebe H, Ferry-Bolder Eve, van Swieten John C, Jiskoot Lize C, Seelaar Harro, Sanchez-Valle Raquel, Laforce Robert, Graff Caroline, Galimberti Daniela, Vandenberghe Rik, de Mendonça Alexandre, Tiraboschi Pietro, Santana Isabel, Gerhard Alexander, Levin Johannes, Sorbi Sandro, Otto Markus, Pasquier Florence, Ducharme Simon, Butler Chris R, Le Ber Isabelle, Tartaglia Maria Carmela, Masellis Mario, Rowe James B, Synofzik Matthis, Moreno Fermin, Borroni Barbara, Kolander Tyler, Mester Carly, Brushaber Danielle, Kantarci Kejal, Heuer Hilary W, Forsberg Leah K, Rohrer Jonathan D, Boeve Bradley F, Boxer Adam L, Rosen Howard J, Finger Elizabeth C

Abstract excerpt

BackgroundConverging evidence hints at neurodevelopmental effects in people at risk of genetic frontotemporal dementia (FTD).ObjectiveWe investigated total intracranial volume (TIV), a neuroimaging marker of neurodevelopment, and years of education differences between adult mutation carriers and familial non-mutation carriers, as measures of the structural and functional neurodevelopmental effects of FTD-causing...

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PMID: 41259271
DOI: 10.1177/13872877251393414
PMCID: PMC12722584

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GRN
MAPT

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