Article
Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: a GENFI study.
Brain : a journal of neurology - 1 Jun 2017
Premi Enrico, Grassi Mario, van Swieten John, Galimberti Daniela, Graff Caroline, Masellis Mario, Tartaglia Carmela, Tagliavini Fabrizio, Rowe James B, Laforce Robert, Finger Elizabeth, Frisoni Giovanni B, de Mendonça Alexandre, Sorbi Sandro, Gazzina Stefano, Cosseddu Maura, Archetti Silvana, Gasparotti Roberto, Manes Marta, Alberici Antonella, Cardoso Manuel J, Bocchetta Martina, Cash David M, Ourselin Sebastian, Padovani Alessandro, Rohrer Jonathan D, Borroni Barbara
Abstract excerpt
Frontotemporal dementia is a heterogeneous neurodegenerative disorder with around a third of cases having autosomal dominant inheritance. There is wide variability in phenotype even within affected families, raising questions about the determinants of the progression of disease and age at onset. It has been recently demonstrated that cognitive reserve, as measured by years of formal schooling, can counteract the...
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