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Article

Mutant p53 and mTOR/PKM2 regulation in cancer cells.

IUBMB life - 1 Sept 2016

Dando Ilaria, Cordani Marco, Donadelli Massimo

Abstract excerpt

Mutations of TP53 gene are the most common feature in aggressive malignant cells. In addition to the loss of the tumor suppressive role of wild-type p53, hotspot mutant p53 isoforms display oncogenic proprieties notoriously referred as gain of functions (GOFs) which result in chemoresistance to therapies, genomic instability, aberrant deregulation of cell cycle progression, invasiveness and enhanced metastatic...

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Identifiers

PMID: 27385486
DOI: 10.1002/iub.1534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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