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PDP1 promotes KRAS mutant colorectal cancer progression by serving as a scaffold for BRAF and MEK1.

Cancer letters - 10 Aug 2024

Yuan Ming, Zhang Chi, Chen Shaopeng, Ye Shubiao, Liu Huashan, Ke Haoxian, Huang Junfeng, Liang Guanzhan, Yu Runfeng, Hu Tuo, Wu Xianrui, Lan Ping

Abstract excerpt

The oncogenic role of KRAS in colorectal cancer (CRC) progression is well-established. Despite this, identifying effective therapeutic targets for KRAS-mutated CRC remains a significant challenge. This study identifies pyruvate dehydrogenase phosphatase catalytic subunit 1 (PDP1) as a previously unrecognized yet crucial regulator in the progression of KRAS mutant CRC. A substantial upregulation of PDP1 expression...

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PMID: 38849010
DOI: 10.1016/j.canlet.2024.217007

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