Article
p53 hotspot mutants attenuate CTL-mediated tumor cell killing through a novel ALKBH5-YTHDF3-PD-L1 pathway.
Oncogene - 1 Sept 2026
Ju Zhuan, Zhang Xiang, Zuo Wenjie, Zhang Lu, Fan Xin, Zhang Chenxing, Zhang Xiaofang, Zhang Xiao, Wang Yidi, Xing Ying, Zuo Baile, Yang Angang, Zhang Rui, Yin Huilong
Abstract excerpt
TP53 is a well-documented tumor suppressor gene frequently mutated in malignancies. It has been demonstrated that the gain-of-function (GOF) mutation of p53 promotes the development and progression of cancers; however, its extrinsic oncogenic mechanisms are still poorly understood. Herein, we found that the oncogenic effect of mutant p53 in vivo is dependent on the tumor immune microenvironment. Importantly, our...
Read the complete abstract on PubMedTopics
- Humans
- Tumor Suppressor Protein p53
- Animals
- RNA-Binding Proteins
- Mice
- B7-H1 Antigen