Article
Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma.
Nature genetics - 1 Oct 2012
Huang Jian, Deng Qing, Wang Qun, Li Kun-Yu, Dai Ji-Hong, Li Niu, Zhu Zhi-Dong, Zhou Bo, Liu Xiao-Yan, Liu Rui-Fang, Fei Qian-Lan, Chen Hui, Cai Bing, Zhou Boping, Xiao Hua-Sheng, Qin Lun-Xiu, Han Ze-Guang
Abstract excerpt
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and shows a propensity to metastasize and infiltrate adjacent and more distant tissues. HCC is associated with multiple risk factors, including hepatitis B virus (HBV) infection, which is especially prevalent in China. Here, we used exome sequencing to identify somatic mutations in ten HBV-positive individuals with HCC with portal vein...
Topics
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Hepatocellular
- Cell Line, Tumor
- Cell Proliferation
- Cell Survival
- Chromosomes, Human, X
- Cyclin-Dependent Kinases
- DNA-Binding Proteins