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Article

Integrated functional genomics-identified DEAF1 in oxidative stress and hepatocellular carcinoma development.

Carcinogenesis - 3 Apr 2025

Huang Linying, Yu Xinyuan, Zhang Ziqi, Huo Yanfei, Zhang Long, Zhang Nasha, Yang Ming

Abstract excerpt

Hepatocellular carcinoma (HCC) is the third most common cause of death for cancer patients globally, with an overall 5-year survival rate of only 16%. The molecular mechanisms leading to malignant progression of HCC patients remain largely unclear. Hepatocyte nuclear factor 4α (HNF4α) functions as a tumor-suppressive transcription factor (TF) in HCC. In this study, we aimed to identify functional HCC...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40554679
DOI: 10.1093/carcin/bgaf032

Genes

DEAF1
SLC38A3
TF

Provenance

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