Article
The frequency of NPM1 mutations in childhood acute myeloid leukemia.
Journal of hematology & oncology - 27 Oct 2010
Braoudaki Maria, Papathanassiou Chrissa, Katsibardi Katerina, Tourkadoni Natalia, Karamolegou Kalliopi, Tzortzatou-Stathopoulou Fotini
Abstract excerpt
BACKGROUND: Mutations in the nucleophosmin (NPM1) gene have been solely associated with childhood acute myeloid leukemia (AML). We evaluated the frequency of NPM1 mutations in childhood AML, their relation to clinical and cytogenetic features and the presence of common FLT3 and RAS mutations. RESULTS: NPM1 mutations were found in 8% of cases. They involved the typical type 'A' mutation and one novel mutation...
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