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Polygenic Risk for Pre-Eclampsia and the Long-Term Risk of Incident Hypertension and Cardiovascular Disease: A Population-Based Cohort Study.

BJOG : an international journal of obstetrics and gynaecology - 1 Mar 2026

Choi Eun-Saem, Jung Sang-Hyuk, Jung Young Mi, Park Chan-Wook, Park Joong Shin, Jun Jong Kwan, Kim Jaeyoung, Kim Beomsu, Cho Chamlee, Shim Injeong, Kim Dokyoon, Won Hong-Hee, Lee Seung Mi

Abstract excerpt

OBJECTIVE: To investigate whether genetic predisposition to pre-eclampsia (PE), measured by a polygenic risk score (PRS), is associated with incident hypertension and cardiovascular disease (CVD) after delivery in Asian women. DESIGN: Prospective population-based cohort study. SETTING: Data were utilised from the Korean Genome and Epidemiology Study and additional multicentre cohorts. POPULATION: 35 872 parous...

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Identifiers

PMID: 41236086
DOI: 10.1111/1471-0528.70072
PMCID: PMC12884253

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