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Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9.

Animal models and experimental medicine - 1 Feb 2026

Chen Wei, Zhang Xu, Fan Rui, Li Xia, Guan Feifei, Wan Gefan, Kong Weining, Qi Xiaolong, Pan Shuo, Shi Sijing, Su Yuanlong, Gao Shan, Huang Wei, Xian Xunde, Liu Jiangning, Wang Yuhui, Ma Yuanwu

Abstract excerpt

BACKGROUND: The golden Syrian hamster is a valuable animal model for studying carcinogenesis, metabolic disorders, cardiovascular diseases, and viral infections due to its biological and pathological similarities to humans. However, the development of genetically engineered hamsters has lagged behind that of mice and rats, largely because of an embryonic development block at the two-cell stage in vitro. Although...

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Alleles
Animals, Genetically Modified
Cricetinae
CRISPR-Cas Systems
Gene Knockout Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microinjections

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PMID: 41235827
DOI: 10.1002/ame2.70107
PMCID: PMC13042419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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