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Article

Polymorphisms in STAT4 and PTPRC genes in rheumatoid arthritis: a Brazilian study and meta-analysis of susceptibility and TNFi response.

Immunologic research - 13 Nov 2025

de Araújo João Locke Ferreira, de Almeida Ingrid Marins, Dos Santos Rodrigues Pedro Augusto Silva, de Sá Garcia Landeiro Lilian, Calmon Laryssa Cardoso, Cruz João Victor Andrade, de Moreira Aramis Tupiná Alcântara, de Oliveira Santos Junison, Pinheiro Gabriela Pimentel, da Cruz Filho Álvaro Augusto Souza, de Figueiredo Camila Alexandrina Viana, de Moura Santos Pablo, Dos Santos Costa Ryan

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Genetic factors play a key role in its pathogenesis and may also influence therapeutic response. This study aimed to investigate the association of the STAT4 rs7574865-T and PTPRC rs10919563-A polymorphisms with RA susceptibility and response to TNF inhibitor (TNFi)...

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Share to Arthritis, Rheumatoid
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Share to Genetic Predisposition to Disease
Share to Polymorphism, Single Nucleotide
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Source

Identifiers

PMID: 41231349
DOI: 10.1007/s12026-025-09719-1

Genes

STAT4
PTPRC
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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