TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy.

doi:10.1155/2015/490295

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Article

TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy.

BioMed research international - 1 Jan 2015

Canhão Helena, Rodrigues Ana Maria, Santos Maria José, Carmona-Fernandes Diana, Bettencourt Bruno F, Cui Jing, Rocha Fabiana L, Canas Silva José, Polido-Pereira Joaquim, Pereira Silva José Alberto, Costa José António, Araujo Domingos, Silva Cândida, Santos Helena, Duarte Cátia, Cáliz Rafael, Filipescu Ileana, Pimentel-Santos Fernando, Branco Jaime, Sainz Juan, Plenge Robert M, Solomon Daniel H, Bruges-Armas Jácome, Da Silva José António P, Fonseca João Eurico, Karlson Elizabeth W

Abstract excerpt

BACKGROUND: The aim of our work was to replicate, in a Southern European population, the association reported in Northern populations between PTPRC locus and response to anti-tumor necrosis factor (anti-TNF) treatment in rheumatoid arthritis (RA). We also looked at associations between five RA risk alleles and treatment response. METHODS: We evaluated associations between anti-TNF treatment responses assessed by...

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PMID: 25834819
DOI: 10.1155/2015/490295
PMCID: PMC4365300

Genes

TNF
PTPRC
TRAF1

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