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Article

Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 Genes Are Associated with the Response to TNF Inhibitors in Patients with Rheumatoid Arthritis.

PloS one - 1 Jan 2017

Conigliaro Paola, Ciccacci Cinzia, Politi Cristina, Triggianese Paola, Rufini Sara, Kroegler Barbara, Perricone Carlo, Latini Andrea, Novelli Giuseppe, Borgiani Paola, Perricone Roberto

Abstract excerpt

OBJECTIVE: Rheumatoid Arthritis (RA) is a progressive autoimmune disease characterized by chronic joint inflammation and structural damage. Remission or at least low disease activity (LDA) represent potentially desirable goals of RA treatment. Single nucleotide polymorphisms (SNPs) in several genes might be useful for prediction of response to therapy. We aimed at exploring 4 SNPs in candidate genes (STAT4,...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 2

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Share to STAT4 Transcription Factor

Share to Tumor Necrosis Factor-alpha

Share to Tumor Necrosis Factor Receptor-Associated Peptides and Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28107378
DOI: 10.1371/journal.pone.0169956
PMCID: PMC5249113

Genes

PTPN2
STAT4
TNF
ADA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 Genes Are Associated with the Response to TNF Inhibitors in Patients with Rheumatoid Arthritis.PMID 28107378Read ↗

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