Genetic and chromatin regulation of Pvt1 monoallelic expression.

Abstract excerpt

While most genes are equivalently expressed on both alleles, genes with random monoallelic expression (RME) stably maintain expression from only one allele, but the mechanisms and consequences of RME remain unclear. We performed allele-specific RNA sequencing (RNA-seq) on ∼100 F1 hybrid neural progenitor cell (NPC) clonal lines to reveal the extent of autosomal RME (aRME). Of the 287 aRME genes, Pvt1, an...

Topics

• Chromatin
• RNA, Long Noncoding
• Alleles
• Animals
• Mice
• Gene Expression Regulation
• DNA Methylation