The loss of microRNA-26b promotes aortic calcification through the regulation of cell-specific target genes.

doi:10.1093/cvr/cvaf117

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The loss of microRNA-26b promotes aortic calcification through the regulation of cell-specific target genes.

Cardiovascular research - 29 Sept 2025

Luna Buitrago Diana, Jover Eva, Mameli Eleonora, Mellis David, Nosalski Ryszard, Charlton Laura, Bauza Sanso Rosa, Dunn-Davies Hywel, MacAskill Mark G, Tavares Adriana A S, Fletcher Alexander J, Nash Jennifer, López-Andrés Natalia, Dweck Marc R, Hadoke Patrick W F, Gilchrist Derek S, Wagner Brad D, Robinson Michael L, Baker Andrew H, Newby David E, Mitić Tijana, Caporali Andrea

Abstract excerpt

AIMS: Vascular calcification is the abnormal deposition of calcium phosphates within blood vessels. This condition is significantly associated with the development of cardiovascular disease, yet the underlying mechanisms remain largely unknown. MicroRNAs (miRNAs) may be crucial in initiating vascular calcification by regulating a network of specific cellular targets. In this study, we explored for the first time...

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PMID: 40737220
DOI: 10.1093/cvr/cvaf117
PMCID: PMC12477678

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SMAD1

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