Article
Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis.
Nature genetics - 1 Dec 2025
Yoshizato Tetsuichi, Nilsson Christer, Grasso Francesca, Högstrand Kari, Mazzi Stefania, Winroth Axel, Lehander Madeleine, Barbosa Indira, Waldin Gunilla, Mortera-Blanco Teresa, Jansson Monika, Widfeldt Mikaela Hillberg, Aliouat Affaf, Brennan Margs S, Markljung Ellen, Hillen Amy, Chari Edwin, Hellström-Lindberg Eva, Kretzschmar Warren W, Woll Petter S, Jacobsen Sten Eirik W
Abstract excerpt
Dynamic steady-state lineage contribution of human hematopoietic stem cell (HSC) clones needs to be assessed over time. However, clonal contribution of HSCs has only been investigated at single time points and without assessing the critical erythroid and platelet lineages. Here we screened for somatic mutations in healthy aged individuals, identifying expanded HSC clones accessible for lineage tracing of all...
Read the complete abstract on PubMedTopics
- Humans
- Cell Lineage
- Hematopoietic Stem Cells
- Hematopoiesis