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Article

MRI-based prediction of DNA methylation grade in IDH-mutant astrocytomas using qualitative imaging features and tumor volumetrics.

Neuroradiology - 1 Dec 2025

Singh Kanwar Partap Bir, Lee Matthew D, Young Matthew G, Orringer Daniel, Wang Yuxiu, Snuderl Matija, Jain Rajan

Abstract excerpt

PURPOSE: Histopathological grading of IDH-mutant astrocytomas demonstrates limited prognostic accuracy. However, DNA methylation subclassification has demonstrated improved prognostication beyond histological grading. This study aimed to investigate the associations between imaging features, tumor volumetric data, and DNA methylation grade in IDH-mutant astrocytomas. METHODS: We analyzed imaging features and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41217503
DOI: 10.1007/s00234-025-03766-z

Genes

CDKN2A

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