Prognostic value of DNA methylation subclassification, aneuploidy, and CDKN2A/B homozygous deletion in predicting clinical outcome of IDH mutant astrocytomas.

doi:10.1093/neuonc/noae009

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Article

Prognostic value of DNA methylation subclassification, aneuploidy, and CDKN2A/B homozygous deletion in predicting clinical outcome of IDH mutant astrocytomas.

Neuro-oncology - 3 Jun 2024

Galbraith Kristyn, Garcia Mekka, Wei Siyu, Chen Anna, Schroff Chanel, Serrano Jonathan, Pacione Donato, Placantonakis Dimitris G, William Christopher M, Faustin Arline, Zagzag David, Barbaro Marissa, Eibl Maria Del Pilar Guillermo Prieto, Shirahata Mitsuaki, Reuss David, Tran Quynh T, Alom Zahangir, von Deimling Andreas, Orr Brent A, Sulman Erik P, Golfinos John G, Orringer Daniel A, Jain Rajan, Lieberman Evan, Feng Yang, Snuderl Matija

Abstract excerpt

BACKGROUND: Isocitrate dehydrogenase (IDH) mutant astrocytoma grading, until recently, has been entirely based on morphology. The 5th edition of the Central Nervous System World Health Organization (WHO) introduces CDKN2A/B homozygous deletion as a biomarker of grade 4. We sought to investigate the prognostic impact of DNA methylation-derived molecular biomarkers for IDH mutant astrocytoma. METHODS: We analyzed...

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PMID: 38243818
DOI: 10.1093/neuonc/noae009
PMCID: PMC11145445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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