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Prediction of Ki-67 labeling index, ATRX mutation, and MGMT promoter methylation status in IDH-mutant astrocytoma by morphological MRI, SWI, DWI, and DSC-PWI.

European radiology - 1 Oct 2023

Yang Xiefeng, Hu Chengcong, Xing Zhen, Lin Yu, Su Yan, Wang Xingfu, Cao Dairong

Abstract excerpt

OBJECTIVE: Noninvasive detection of molecular status of astrocytoma is of great clinical significance for predicting therapeutic response and prognosis. We aimed to evaluate whether morphological MRI (mMRI), SWI, DWI, and DSC-PWI could predict Ki-67 labeling index (LI), ATRX mutation, and MGMT promoter methylation status in IDH mutant (IDH-mut) astrocytoma. METHODS: We retrospectively analyzed mMRI, SWI, DWI, and...

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PMID: 37133522
DOI: 10.1007/s00330-023-09695-w

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