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Article

T2-FLAIR Mismatch Sign Predicts DNA Methylation Subclass and CDKN2A/B Status in IDH-Mutant Astrocytomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2024

Lee Matthew D, Jain Rajan, Galbraith Kristyn, Chen Anna, Lieberman Evan, Patel Sohil H, Placantonakis Dimitris G, Zagzag David, Barbaro Marissa, Guillermo Prieto Eibl Maria Del Pilar, Golfinos John G, Orringer Daniel A, Snuderl Matija

Abstract excerpt

PURPOSE: DNA methylation profiling stratifies isocitrate dehydrogenase (IDH)-mutant astrocytomas into methylation low- and high-grade groups. We investigated the utility of the T2-fluid-attenuated inversion recovery (T2-FLAIR) mismatch sign for predicting DNA methylation grade and cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) homozygous deletion, a molecular biomarker for grade 4 IDH-mutant astrocytomas,...

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PMID: 38829583
DOI: 10.1158/1078-0432.CCR-24-0311
PMCID: PMC11326959

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