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Article

Diagnostic discrepancies in malignant astrocytoma due to limited small pathological tumor sample can be overcome by IDH1 testing.

Journal of neuro-oncology - 1 Jun 2014

Kim Betty Y S, Jiang Wen, Beiko Jason, Prabhu Sujit S, DeMonte Franco, Gilbert Mark R, Sawaya Raymond, Aldape Kenneth D, Cahill Daniel P, McCutcheon Ian E

Abstract excerpt

The accurate grading of malignant astrocytomas has significant prognostic and therapeutic implications. Traditional histopathological grading can be challenging due to regional tumor heterogeneity, especially in scenarios where small amounts of tissue are available for pathologic review. Here, we hypothesized that a critical tumor resection volume is needed for correct grading of astrocytomas by histopathology....

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Source

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Identifiers

PMID: 24777756
DOI: 10.1007/s11060-014-1451-0
PMCID: PMC4386582

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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