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Overexpression of AdeIJK RND efflux pump in Acinetobacter baumannii using the mini-Tn 7 T-based single copy induction system can lead to lacIq mutation.

Microbiology spectrum - 2 Dec 2025

Wimalasekara Ruwani L, Patidar Rakesh, White Dawn, Kumar Ayush

Abstract excerpt

Chromosomal gene complementation with inducible expression is a powerful approach for investigating bacterial gene function. The pUC18T-mini-Tn7T system enables isopropyl β-D-1-thiogalactopyranoside (IPTG)-inducible, site-specific genomic integration of genes in single copy via the Ptac-lacI q regulatory system. While widely used, limitations remain underexplored. Here, we report a rare and possibly...

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Identifiers

PMID: 41211987
DOI: 10.1128/spectrum.01609-25
PMCID: PMC12671198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Overexpression of AdeIJK RND efflux pump in Acinetobacter baumannii using the mini-Tn 7 T-based single copy induction system can lead to lacIq mutation.PMID 41211987Read ↗

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