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Lifestyle patterns, genetic susceptibility, and risk of valvular heart disease: a prospective cohort study based on the UK Biobank.

European journal of preventive cardiology - 26 Oct 2023

Jia Chenglin, Zeng Yu, Huang Xuan, Yang Huazhen, Qu Yuanyuan, Hu Yao, Chen Wenwen, Yang Xiaoyan

Abstract excerpt

AIMS: Genetic and lifestyle factors are both major contributors to valvular heart disease (VHD). However, it is still uncertain whether genetic susceptibility alters the association between lifestyle and VHD. We aimed to investigate the association between lifestyle and VHD in different genetic risk backgrounds. METHODS AND RESULTS: A prospective cohort study was carried out on 499 341 participants without VHD at...

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PMID: 37259902
DOI: 10.1093/eurjpc/zwad177

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