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Dimeric <sup>R25C</sup> PTH(1-34) Activates the Parathyroid Hormone-1 Receptor <i>in vitro</i> and Stimulates Bone Formation in Osteoporotic Female Mice

2024-03-14

Abstract excerpt

Osteoporosis, characterized by reduced bone density and strength, increases fracture risk, pain, and limits mobility. Established therapies of Parathyroid hormone (PTH) analogs effectively promote bone formation and reduce fractures in severe osteoporosis, but their use is limited by potential adverse effects. In the pursuit of safer osteoporosis treatments, we investigated R25C PTH, a PTH variant wherein the nat...

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Literature Corpus work
38d2dfb1-1da1-56e4-afbd-86caaf6b23ae
DOI
10.1101/2024.03.13.584815
Open publication

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Dimeric <sup>R25C</sup> PTH(1-34) Activates the Parathyroid Hormone-1 Receptor <i>in vitro</i> and Stimulates Bone Formation in Osteoporotic Female MiceDOI 10.1101/2024.03.13.584815
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