Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of clonal selection by multicolor flow cytometry in TAM with multiple GATA1 mutations.

International journal of hematology - 1 Feb 2026

Kohso Atsushi, Iwamoto Shotaro, Niwa Kaori, Nannya Yasuhito, Toki Tsutomu, Hanaki Ryo, Toyoda Hidemi, Deguchi Takao, Ogawa Seishi, Terui Kiminori, Ito Etsuro, Hirayama Masahiro

Abstract excerpt

Transient abnormal myelopoiesis (TAM) occurs in approximately 10% of neonates with Down syndrome (DS), and about 20% of these cases progress to myeloid leukemia associated with DS (ML-DS) within the first four years of life. TAM usually arises from a single clone harboring an identical GATA1 mutation, but approximately 8% of cases carry heterogeneous clones with distinct GATA1 mutations. To date, no reliable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clone Cells
Share to Cytarabine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down Syndrome

Share to Flow Cytometry

Share to GATA1 Transcription Factor

Share to Infant

Share to Infant, Newborn

Share to Mutation

Source

Identifiers

PMID: 41201769
DOI: 10.1007/s12185-025-04101-1

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of clonal selection by multicolor flow cytometry in TAM with multiple GATA1 mutations.PMID 41201769Read ↗

GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia.Semantic proximity Read ↗

Recent advances in the understanding of transient abnormal myelopoiesis in Down syndromeSemantic proximity Read ↗

Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesisSemantic proximity Read ↗

Sensitive GATA1 mutation screening reliably identifies neonates with Down syndrome at risk for myeloid leukemiaSemantic proximity Read ↗

Complete blood count differences in a cohort of Down syndrome neonates with transient abnormal myelopoiesis screened for GATA1 pathogenic variants.Semantic proximity Read ↗

Acute megakaryoblastic leukemia with acquired trisomy 21 and GATA1 mutations in phenotypically normal children.Semantic proximity Read ↗

Clinical significance of preleukemic somatic GATA1 mutations in children with Down syndromeSemantic proximity Read ↗

Post-transplant transient abnormal myelopoiesis evolving from a GATA1 mutant clone in umbilical cord blood.Semantic proximity Read ↗

Acute megakaryoblastic leukemia associated with trisomy 21 demonstrates a distinct immunophenotypeSemantic proximity Read ↗

Transient abnormal myelopoiesis in neonates: GATA get the diagnosis.Semantic proximity Read ↗

Neonatal GATA1 mutant clones under the radar.Semantic proximity Read ↗

Development of acute megakaryoblastic leukemia from a minor clone in a Down syndrome patient with clinically overt transient myeloproliferative disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.