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Post-transplant transient abnormal myelopoiesis evolving from a GATA1 mutant clone in umbilical cord blood.

Annals of hematology - 1 Dec 2024

Kubota Yusuke, Sakurai Masatoshi, Nannya Yasuhito, Kogure Yasunori, Shiroshita Kohei, Fujita Shinya, Yamaguchi Kentaro, Mizuno Kota, Kato Jun, Mori Takehiko, Ogawa Seishi, Kataoka Keisuke

Abstract excerpt

Transient abnormal myelopoiesis (TAM) generally affects newborns with Down syndrome and is associated with constitutional trisomy 21 and a somatic GATA1 mutation. Here we describe a case of TAM which evolved after umbilical cord blood transplantation (UCBT), whose origin was identified as a GATA1 mutation-harboring clone in umbilical cord blood (UCB) by detailed genetic analyses. A 58-year-old male who received...

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PMID: 39665979
DOI: 10.1007/s00277-024-06123-x

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