Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An iPSC-derived model for drug screening in cerebral small vessel disease.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Jun 2026

Granata Alessandra, Al-Thani Maha, Goodwin-Trotman Mary, Smith David M, Van Agtmael Tom, Markus Hugh S

Abstract excerpt

Despite the enormous health importance of cerebral small vessel disease (cSVD) there are few treatments available. A major limitation in screening new therapies is a lack of clinically relevant disease models. Induced pluripotent stem cell (iPSC) technology allows creation of in vitro models of the vascular unit, which is found to be affected in cSVD. Here we derived iPSC from skin biopsies obtained from patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood-Brain Barrier
Share to Cerebral Small Vessel Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coculture Techniques

Share to Collagen Type IV

Share to Drug Evaluation, Preclinical

Share to Endothelial Cells

Share to High-Temperature Requirement A Serine Peptidase 1

Share to Matrix Metalloproteinase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 41200916
DOI: 10.1177/0271678X251389379
PMCID: PMC12597805

Genes

COL4A1
HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An iPSC-derived model for drug screening in cerebral small vessel disease.PMID 41200916Read ↗

A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases in extracellular matrix abnormalitiesSemantic proximity Read ↗

A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinasesSemantic proximity Read ↗

Establishment of a novel patient hiPSC-derived in vitro blood-brain barrier model of collagen IV small vessel diseaseSemantic proximity Read ↗

Harnessing iPSCs, 3D organoids, and multiomics to model rare vascular diseases: Emerging new approach methodologies.Semantic proximity Read ↗

HTRA1 deficiency in <i>COL4A1</i> mutant hiPSC-derived astrocytes: a convergent mechanism of cerebral small vessel diseaseSemantic proximity Read ↗

Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease.Semantic proximity Read ↗

Loss of col4a1 in zebrafish recapitulates the cerebrovascular phenotypes associated with monogenic cerebral small vessel disease.Semantic proximity Read ↗

Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease CADASILSemantic proximity Read ↗

Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and LeukoencephalopathySemantic proximity Read ↗

Targeting COL4A1-Related Small Vessel Disease: Repurposed Pharmacotherapies for Genetic VasculopathiesSemantic proximity Read ↗

Pericyte Loss Reprogrammes Capillary Endothelium and Drives White Matter Injury in Small Vessel DiseaseSemantic proximity Read ↗

Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous MalformationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.