Blood methylome signatures in children exposed to maternal type 1 diabetes are linked to protection against islet autoimmunity.

doi:10.1038/s42255-025-01403-w

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Article

Blood methylome signatures in children exposed to maternal type 1 diabetes are linked to protection against islet autoimmunity.

Nature metabolism - 1 Nov 2025

Ott Raffael, Zapardiel-Gonzalo Jose, Kreitmaier Peter, Casteels Kristina, Hommel Angela, Kordonouri Olga, Elding Larsson Helena, Szypowska Agnieszka, Vatish Manu, Zeggini Eleftheria, Knopff Annette, Winkler Christiane, Ziegler Anette-G, Bonifacio Ezio, Hummel Sandra

Abstract excerpt

Exposure to maternal type 1 diabetes (T1D) during pregnancy provides relative protection against T1D in the offspring. This protective effect may be driven by epigenetic mechanisms. Here we conducted an epigenome-wide blood analysis on 790 young children with and 962 children without a T1D-affected mother, and identified differential DNA methylation (q < 0.05) at multiple loci and regions. These included the...

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Topics

Humans
Diabetes Mellitus, Type 1
Female
Autoimmunity
DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Pregnancy

Islets of Langerhans

Epigenome

Male

Child

Epigenesis, Genetic

Child, Preschool

Prenatal Exposure Delayed Effects

Genetic Predisposition to Disease

Source

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Identifiers

PMID: 41198985
DOI: 10.1038/s42255-025-01403-w
PMCID: PMC12638243

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