Tumor mutational burden modulates the prognostic effect of RAS mutations in metastatic colon cancer: mechanistic insights and genotype-phenotype correlations.

doi:10.1186/s12967-025-07273-w

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Article

Tumor mutational burden modulates the prognostic effect of RAS mutations in metastatic colon cancer: mechanistic insights and genotype-phenotype correlations.

Journal of translational medicine - 5 Nov 2025

Ianniello Monica, Ottaiano Alessandro, Bocchetti Marco, Ruggiero Raffaella, Santorsola Mariachiara, Sirica Roberto, Caraglia Francesco, Ceccarelli Anna, Toscano Enrica, Picone Carmine, Ciappina Giuliana, Cossu Alessia Maria, Petrillo Nadia, Fico Antonio, Circelli Luisa, Sabbatino Francesco, Barone Antonio, Sperlongano Rossella, Berretta Massimiliano, Caraglia Michele, Savarese Giovanni

Abstract excerpt

BACKGROUND: RAS mutations, present in 40-50% of metastatic colorectal cancer (mCRC) cases, drive oncogenic signaling and confer resistance to anti-EGFR therapies. Tumor mutational burden (TMB), a marker of genomic instability, has recently emerged as a predictive biomarker of response to immunotherapy. However, the prognostic interaction between RAS status and TMB in mCRC remains poorly defined. PATIENTS AND...

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PMID: 41194193
DOI: 10.1186/s12967-025-07273-w
PMCID: PMC12587636

Genes

APC
TP53
BRCA1
EGFR
ERBB2

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