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Article

Quantitative ctDNA Profiling of RAS Mutations as a Prognostic Biomarker in Metastatic Colorectal Cancer.

International journal of molecular sciences - 19 Dec 2025

Chibaudel Benoist, Carola Elisabeth, Mekranter Hamid, Goyer Perrine, Saget Arnaud, Oberlin Olivier, Marijon Hélène, Richa Hubert, Iurisci Ida, Gervais Honorine, Perez-Staub Nathalie, Dainese Linda, Pujol Pascal, Toledano Alain, Bachet Jean-Baptiste, de Gramont Aimery

Abstract excerpt

Circulating tumor DNA (ctDNA) analysis offers a non-invasive approach to molecular profiling. While RAS mutations are well-established predictive biomarkers in metastatic colorectal cancer (mCRC), the prognostic value of their variant allele frequency (VAF) remains unclear. We retrospectively analyzed individual patient data with mCRC who underwent ctDNA testing using the FoundationOne® Liquid CDx assay. The...

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Aged
Biomarkers, Tumor
Circulating Tumor DNA
Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Metastasis

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Open in PubMed Open full text

Identifiers

PMID: 41515890
DOI: 10.3390/ijms27010008
PMCID: PMC12785939

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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