Molecular Profiling in Metastatic Colorectal Cancer.

doi:10.46883/ONC.2020.3409.0352

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Article

Molecular Profiling in Metastatic Colorectal Cancer.

Oncology (Williston Park, N.Y.) - 15 Sept 2020

Armstrong Samantha A, Malley Rita, Weinberg Benjamin A

Abstract excerpt

Colorectal cancer (CRC) is a commonly diagnosed malignancy. Although chemotherapy remains the backbone of treatment, the landscape of treating metastatic CRC (mCRC) is changing with the understanding of its heterogeneity and molecular blueprint. Colon cancer sidedness has proven to hold prognostic implications, with right-sided tumors having higher incidence of BRAF and KRAS mutations and being microsatellite...

Topics

Biomarkers, Tumor
Colorectal Neoplasms
Genes, ras
Humans
Microsatellite Instability
Molecular Targeted Therapy
Mutation
Neoplasm Metastasis
Oncogene Fusion
Prognosis
Proto-Oncogene Proteins B-raf
Receptor, ErbB-2
Receptor, trkA

Source

Open in PubMed

Identifiers

PMID: 32965665
DOI: 10.46883/ONC.2020.3409.0352

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