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Article

Identifying the Shared Metabolite Biomarkers and Potential Intervention Targets for Multiple Sarcopenia-Related Phenotypes.

International journal of molecular sciences - 16 Nov 2024

Luo Jia, Li Jingxian, Wang Weijing, Zhang Ronghui, Zhang Dongfeng

Abstract excerpt

The relationship between circulating metabolites and sarcopenia-related phenotypes remains unclear. We explored the causality between circulating metabolites and sarcopenia-related phenotypes. Instrumental variables for the human metabolome were derived from the recently published GWAS, which included 690 plasma metabolites. Summary statistics for four sarcopenia phenotypes (whole-body lean mass (WBLM), usual...

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Aged
Biomarkers
Genome-Wide Association Study
Hand Strength
Metabolome

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Polymorphism, Single Nucleotide

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PMID: 39596375
DOI: 10.3390/ijms252212310
PMCID: PMC11594328

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