Association between NAFLD and liver cancer: A two-sample Mendelian randomization study.

Abstract excerpt

Observational studies suggest an association between nonalcoholic fatty liver disease (NAFLD) and liver cancer, but its causal nature remains unclear. A 2-sample Mendelian randomization (MR) analysis was performed using NAFLD and liver cancer summary statistics from genome-wide association study databases. Instrumental variables satisfying the 3 core MR assumptions were selected. Causal effects were estimated...

Topics

• Humans
• Non-alcoholic Fatty Liver Disease
• Mendelian Randomization Analysis
• Liver Neoplasms
• Genome-Wide Association Study
• Polymorphism, Single Nucleotide