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Article

Comprehensive Analysis of Genomic Variations in Pancreatic Adenocarcinoma by Race.

Cancer medicine - 1 Nov 2025

El Moheb Mohamad, Cummins Kaelyn C, Shen Chengli, Bitar Elio R, Kim Susan J, Mayhew Mackenzie M, Zhang Hongji, Witt Russell G, Ruff Samantha M, Tsung Allan

Abstract excerpt

PURPOSE: Racial disparities in pancreatic ductal adenocarcinoma (PDAC) incidence and outcomes persist even after adjusting for access to care and treatment received, suggesting a role for tumor-specific molecular factors. This study aimed to compare the mutational landscape of PDAC tumor samples across racial groups using a large, diverse patient cohort. METHODS: Genetic variations were analyzed using data from...

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Source

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Identifiers

PMID: 41187942
DOI: 10.1002/cam4.71346
PMCID: PMC12585320

Genes

CDKN2A
ARID1A
COL7A1
KMT2D
KRAS
RNF43
SMAD4
TP53

Provenance

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