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Article

Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role.

Biochimica et biophysica acta. Molecular cell research - 1 Jan 2026

Koutouan Evodie, Lillo Alejandro, Kabashima Ayano, Sample Jack W, Carlson Danielle, Graham Rondell, Smoot Rory L, Pasquale Elena B

Abstract excerpt

Although EPHA2 is a receptor tyrosine kinase widely expressed in many cancers, it exhibits a uniquely high frequency of coding sequence mutations in cholangiocarcinoma, a cancer of the biliary tract with dismal prognosis. EPHA2 is extensively studied, but very little is known about the role of EPHA2 cancer mutations. To define the functional significance of EPHA2 mutations in biliary tract cancers, we generated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41187859
DOI: 10.1016/j.bbamcr.2025.120081
PMCID: PMC13005928

Genes

EPHA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role.PMID 41187859Read ↗

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