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Article

The Charge-driven Engineering of Mnemiopsin 2: Impact of Serine 35 Mutation on Activity and Stability.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology - 1 Nov 2025

Mohammadi Amirreza, Jafarian Vahab, Khalifeh Khosrow, Shirdel Akram, Khatami Fatemeh

Abstract excerpt

Bioluminescence in marine organisms, driven by photoproteins like mnemiopsin 2 from Mnemiopsis leidyi, relies on calcium-regulated light emission. This study investigates the functional and structural effects of site-directed mutagenesis at serine 35 in mnemiopsin 2, replacing it with lysine or glutamic acid to explore charge and polarity impacts on the structure and function of the photoprotein. Homology...

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Identifiers

PMID: 41186848
DOI: 10.1007/s43630-025-00804-w

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