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Article

Genetic Downregulation of Interleukin-6 Signaling, Coagulation Function, and Risk of Thromboembolic Disease.

Journal of the American Heart Association - 16 Dec 2025

Daghlas Iyas, Gill Dipender

Abstract excerpt

BACKGROUND: Although genetic evidence supports IL-6 (interleukin-6) signaling inhibition as protective against atherosclerotic disease, its potential effects on thromboembolic outcomes are not well established. We conducted a Mendelian randomization analysis to investigate the association of genetically proxied IL-6 signaling inhibition with venous thromboembolism, cardioembolic stroke, and coagulation cascade...

Read the complete abstract on PubMed

Topics

Humans
Interleukin-6
Mendelian Randomization Analysis
Blood Coagulation
Signal Transduction
Venous Thromboembolism

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Risk Factors

Genome-Wide Association Study

Down-Regulation

Male

C-Reactive Protein

Female

Risk Assessment

Receptors, Interleukin-6

Genetic Predisposition to Disease

Embolic Stroke

Polymorphism, Single Nucleotide

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 41378496
DOI: 10.1161/JAHA.125.043972
PMCID: PMC12826935

Genes

CRP
IL6R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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