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Article

Loop-mediated isothermal amplification assays for the rapid discrimination of Treponema pallidum lineages and subspecies.

Microbiology spectrum - 2 Dec 2025

Imai Kazuo, Ohama Yuki, Sato Akihiro, Tanaka Masashi, Omachi Ryuha, Takeuchi Keita, Mizushina Hitomi, Nakayama Shu-Ichi, Maeda Takuya, Akeda Yukihiro

Abstract excerpt

Molecular surveillance aimed at identifying the subspecies and lineages of Treponema pallidum is important. Conventional molecular methods for genotyping are effective but are also time-consuming and costly. This study aimed to develop and evaluate a novel loop-mediated isothermal amplification (LAMP) method using quenching probes to quickly distinguish T. pallidum subsp. pallidum lineages (Nichols, SS14Ω-A,...

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Identifiers

PMID: 41165365
DOI: 10.1128/spectrum.01565-25
PMCID: PMC12671098

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