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Molecular investigation of Treponema pallidum strains associated with ocular syphilis in the United States, 2016-2020.

Microbiology spectrum - 3 Oct 2024

Pillay Allan, Vilfort Kendra, Debra Alyssa, Katz Samantha S, Thurlow Charles M, Joseph Sandeep J, Lundy Stephanie, Ji Andrew, Jaeyoung Hong, Workowski Kimberly A, Barrow Roxanne Y, Danavall Damien, Pettus Kevin, Chi Kai-Hua, Kersh Ellen N, Cao Weiping, Chen Cheng Y

Abstract excerpt

Ocular syphilis is a serious complication of Treponema pallidum infection that can occur at any stage of syphilis and affect any eye structure. It remains unknown if certain T. pallidum strains are associated with ocular infections; therefore, we performed genotyping and whole genome sequencing (WGS) to characterize strains from patients with ocular syphilis. Seventy-five ocular or non-ocular specimens from 55...

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Identifiers

PMID: 39162489
DOI: 10.1128/spectrum.00581-24
PMCID: PMC11448083

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