Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zebrafish as a model for Catel-Manzke syndrome-identification and characterization of the zebrafish TGDS ortholog.

The FEBS journal - 1 Apr 2026

Coppola Maria Rosaria, Bellitto Deianira, Asgari Erfan, Bazzurro Virginia, Casucci Giorgia, Piacente Francesco, Bozzo Matteo, Ceresa Davide, Parisi Costantino, Winata Cecilia, Candiani Simona, Tonetti Michela

Abstract excerpt

Catel-Manzke syndrome (CMS) is a rare genetic disorder associated with mutations in the TDP-glucose 4,6-dehydratase (TGDS) gene, the function of which in vertebrates remains unclear. This study investigated the zebrafish ortholog tgds to assess its suitability for modeling the disease. During development, the tgds transcript exhibits a conserved biphasic expression pattern with an initial maternal contribution...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Cas Systems
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Mutation

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 41159851
DOI: 10.1111/febs.70307
PMCID: PMC13080230

Genes

TGDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zebrafish as a model for Catel-Manzke syndrome-identification and characterization of the zebrafish TGDS ortholog.PMID 41159851Read ↗

Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development.Semantic proximity Read ↗

O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder.Semantic proximity Read ↗

Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome.Semantic proximity Read ↗

A single heterozygous mutation in <i>COG4</i> disrupts zebrafish early development via Wnt signalingSemantic proximity Read ↗

Abnormal cartilage development and altered N-glycosylation in Tmem165-deficient zebrafish mirrors the phenotypes associated with TMEM165-CDG.Semantic proximity Read ↗

Impaired fertility and motor function in a zebrafish model for classic galactosemia.Semantic proximity Read ↗

A novel phosphoglucomutase‐deficient mouse model reveals aberrant glycosylation and early embryonic lethalitySemantic proximity Read ↗

Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis.Semantic proximity Read ↗

<i>b3galt6</i> knock-out zebrafish recapitulate β3GalT6-deficiency disorders in human and reveal a trisaccharide proteoglycan linkage regionSemantic proximity Read ↗

Repurposing the HMG-CoA Reductase Inhibitor Atorvastatin for SRD5A3-CDGSemantic proximity Read ↗

The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathiesSemantic proximity Read ↗

The emerging use of zebrafish to model metabolic disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.