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Article

The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies

4 Feb 2011

Abstract excerpt

In a forward genetic approach to identify novel genes for congenital muscle diseases, a zebrafish mutant, designated patchytail, was identified that exhibits degenerating muscle fibers with impaired motility behavior. Genetic mapping identified a genomic locus containing the zebrafish ortholog of the dystroglycan gene (DAG1). Patchytail fish contain a point mutation (c.1700T>A) in dag1, resulting in a missense...

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PMID: 21296866
DOI: 10.1093/hmg/ddr047

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