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<i>b3galt6</i> knock-out zebrafish recapitulate β3GalT6-deficiency disorders in human and reveal a trisaccharide proteoglycan linkage region

2020-06-23

Abstract excerpt

Proteoglycans are structurally and functionally diverse biomacromolecules found abundantly on cell membranes and in the extracellular matrix. They consist of a core protein linked to glycosaminoglycan chains via a tetrasaccharide linkage region. Here, we show that CRISPR/Cas9-mediated b3galt6 knock-out zebrafish, lacking galactosyltransferase II, which adds the third sugar in the linkage region, largely recapitul...

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Literature Corpus work
febfc254-a44a-59c8-bc4f-b6953d09cc4b
DOI
10.1101/2020.06.22.165316
Open publication

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