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Article

A multiscale screening platform for rapid GPCR variant profiling reveals color-tuned JSR1 mutants.

Biophysical journal - 19 May 2026

Mühle Jonas, Walter Deborah, Griebl Marielouise, Schertler Gebhard F X

Abstract excerpt

Integral membrane proteins such as G-protein-coupled receptors (GPCRs), including visual pigments, are critical targets in both fundamental and pharmaceutical research. However, low expression levels and intrinsic instability often hinder their functional and structural characterization. Therefore, efficient screening methods are needed to identify suitable candidates for biochemical and biophysical analysis....

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Identifiers

PMID: 41157946
DOI: 10.1016/j.bpj.2025.10.034
PMCID: PMC13351981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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