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Article

Rhobot-Screen: an integrated robotic platform for functional screening of rhodopsin variants.

BMC biology - 6 Aug 2026

Nagata Takashi, Konno Masae, Hashimoto Daisuke R, Inoue Keiichi

Abstract excerpt

BACKGROUND: Rhodopsins are photoreceptive membrane proteins widely used as optogenetic tools in basic research and medical applications, and extensive mutational studies have been performed to improve or modify their functional properties. Recently, in the broader field of protein engineering, data-driven strategies based on machine learning have attracted increasing attention, as they enable efficient...

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PMID: 42557568
DOI: 10.1186/s12915-026-02691-8
PMCID: PMC13445694

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