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Article

A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.

Investigative ophthalmology & visual science - 1 Apr 2015

Chen Yuanyuan, Tang Hong, Seibel William, Papoian Ruben, Li Xiaoyu, Lambert Nevin A, Palczewski Krzysztof

Abstract excerpt

PURPOSE: Inherent instability of the P23H mutant opsin accounts for approximately 10% of autosomal dominant retinitis pigmentosa cases. Our purpose was to develop an overall set of reliable screening strategies to assess if either stabilization or enhanced degradation of mutant rhodopsin could rescue rod photoreceptors expressing this mutant protein. These strategies promise to reveal active compounds and clarify...

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Source

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Identifiers

PMID: 25783607
DOI: 10.1167/iovs.14-16298
PMCID: PMC4554260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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