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Article

Polygenic risks and cardiovascular treatment effects in severe mental illness.

Psychiatric genetics - 1 Dec 2025

Yao Kai, Burton Alexandra, Heinkel Samira, Osborn David, Bass Nick, McQuillin Andrew

Abstract excerpt

OBJECTIVE: Patients with severe mental illness (SMI) experience increased cardiovascular risks, leading to reduced life expectancy. Polygenic risk scores (PRS) prediction is promising for assessing cardiovascular risks. This study evaluated the predictive utility of cardiovascular PRS and the impact from risk-reducing interventions among patients with SMI. METHODS: Using samples from the PRIMROSE programme,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41157930
DOI: 10.1097/YPG.0000000000000401
PMCID: PMC12588646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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